MicroFlow NMR

MicroFlow NMR Journal Papers

Open Access
HT-NMR Intro

 

Welcome to Magnetic Resonance Microsensors, a subsidiary of Protasis Corporation since August, 2001.  Located near the University of Illinois at Urbana/Champaign and the Beckman Institute, we bring the analytical research community the highest mass sensitivity attainable using miniaturized nuclear magnetic resonance (NMR) detector flowcells and microcoils.

MRM was formed by Timothy Peck, Jonathan Sweedler, Andrew Webb and Richard Magin to explore the benefits of miniaturization and integration, applied to NMR.  Supported by several SBIR grants and early adopters, this initiative has produced breakthrough success.

Integrated with and embedded into complementary Waters CapLCTM and Bruker, Varian and JEOL NMR instruments, MRM’s patented, microcoil (five microliter volume) CapNMRTM probes dramatically improve mass sensitivity of trace quantity samples.  MicroFlow NMR typically allow high-quality spectra to be obtained with a single microgram of material, effectively enabling many new applications (e.g., metabolites, impurities) for the first time.

Because NMR is an integrating detector, use of a microliter-volume flowcells dramatically reduces signal acquisition times by as much as a hundred-fold over conventional probes for equivalent spectra.  The enables NMR as an informed-high throughput screening technique.  Correlation spectra, previously too slow and requiring too much material can now give definitive information on drug lead structure, protein-ligand binding constants, etc.



Now get exceptional
NMR spectra...

With a single drop of your valuable sample...

In perfect balance

=> High sensitivity
and
high speed.