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Medicinal
Chemistry |
Bernhard
Geierstanger et al,
Genomics
Institute of the Novartis Research Foundation
This general-purpose NMR facility supports a diverse range of
natural products, medicinal chemistry and metabolism
applications. One-Minute NMR is installed on a dedicated
Bruker 400 MHz system and is used routinely to process samples
from a group of about twenty medicinal chemists. The aggregation of
synthesis confirmation samples from an entire department keeps the system busy processing
hundreds of 1D and 2D samples every month.
Read
recent Press Release about Analytical Chemistry article |
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Natural
Products,
Insects |
Frank Schroeder,
et al
Cornell University
This research group demonstrated elucidation of thirteen
steroids extracted from fifty fireflies and cleaned up with
HPLC. The amounts of steroid in each HPLC fraction,
40–150 nmol, were below the detection levels for
conventional NMR with Shigemi tubes, resulting in a
threefold improvement in signal-to-noise ratio. The active
volume of the flow cell is 3µL, compared with 0.5 mL in a
conventional probe. A complete suite of proton and
correlation spectra were acquired using a MicroFlow NMR
probe and a Manual Injector Module. Assignment data
and comparisons with Shigemi tubes are available.
Read recent Press Release in the Royal Society of Chemistry:
Chemistry World |
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Natural
Products,
Plants |
Mark O'Neil Johnson, et al
Sequoia Sciences
The unprecedented mass sensitivity of the microflow NMR probe coupled with the
high-throughput, microfluidic sample manager developed expressly for use with
the flowprobes, now allows Sequoia to acquire 1D proton and 2D Gradient COSY NMR
spectra on quantities of less than 10 micrograms in under ten minutes in its
pursuit of rapid structure elucidation. Sequoia was among the first companies to
validate the MRM microflow probe when introduced in 2001 and was the first to
use the indirect Proton/Carbon Gradient probe. With the aid of
this probe, they have been able to identify greater than twenty new molecular
entities (NME’s) within the past six months, a remarkable achievement in drug
discovery productivity. The two prongs of Sequoia’s successful strategy are: (1)
purification optimized by multi-stage separations methods and (2) structure
elucidation using micro-scale NMR. This strategy dovetails with Protasis’
mission as a discovery tools provider.
Read
groundbreaking Analytical Chemistry article describing
Sequoia's unique approach.
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