NMR analysis has entered a new domain.  MicroFlow NMR promises to yield more information from smaller quantities of sample and solvent, at significantly lower cost.

The marriage of Waters capillary liquid chromatography and MRM capillary NMR probes attains the ultimate mass sensitivity achievable in your magnet.  These newly-released and purpose-designed capillary-scale sample management platforms optimize fluidic matching flowcell filling between CapLC^tm and CapNMR^tm.  The gains in S/N achieved using this hyphenated approach represent an essential value to the user, who can decide, based on specific application demands, how to best spend their increased sensitivity budget: use less sample, use a shorter acquisition time, or take advantage of a compromise strategy.

CapNMR^TM Probe for Waters CapLC^TM

For the highest level of performance in LC-NMR, Waters and Protasis MRM have joined forces to match the NMR detector flowcell to the exact flow characteristics of capillary LC.  One peak volume from a capillary column perfectly fits into our NMR flowcell.  Natural product screening and metabolic profiling are particularly suited to this powerful combination of separation and structure--and the sample is still available for mass spectrometry!

HT-NMR^TM Probe for High Throughput Sample Loading

For drug discovery applications where speed and/or multiplexing is needed, Protasis can retrofit most existing liquid handlers to park microaliquots of sample precisely in the NMR detector flow cell.  We use our smart Micro Sample Management System to rapidly position your 5 microliter sample into its parking space (i.e., flowcell), each and every time.  Letting you screen faster!  Designed and proven for the popular Gilson 215, contact us for availability for your liquid handler.

Dynamic Focusing^TM for Pre-Concentrating NMR Samples

In NMR applications where accumulation and pre-concentration are required, Protasis will deploy dynamic field gradient focusing (DFGF).  Although still under development, this new ultra-high-resolution technique has already demonstrated chiral separations without ampholytes and offers great promise for work with low abundance proteins and similarly difficult bio-purification problems.  We are now seeking contract research sponsors for high-value proteomics applications.  Contact us for details.