Built for Speed:   Protasis/MRM's HT-NMR Probe  for High Throughput Drug Discovery
We believe that the most important issue to our customers is their sample...	so from your liquid handler,	we'll get your sample to the probe quickly...	and then get you safely parked! add spectra here

Introducing HT-NMR™  -  the world’s first true MicroFlow NMR probe for high throughput!

MRM’s capillary µFlowProbes constitute a 100% fused silica capillary solution to NMR analysis. All wetted surfaces of the probe are fused silica, thereby maximizing solvent compatibility. Solvent consumption is drastically reduced over conventional-scale systems, making the use of NMR-compatible (deuterated) solvents cost effective and practical. MRM probes are engineered, manufactured, and calibrated to extremely high standards, so that sample management is reliable and accurate. MRM probes are easy to use, reliable to operate, and adaptable to all major NMR spectrometer systems. 

MRM’s µFlowProbe™ Engineered for Unparalleled Performance

MRM’s µFlowProbe™ utilizes a unique, patented NMR detection module that provides excellent spectral resolution while maintaining high fill factor, designed to ensure that the majority of the active region of the RF coil is filled with sample. This provides the highest mass sensitivity of any commercial flow probe.  Only 5 microliters of your valuable drug lead is require to fill the flowcell.  Only 7 microliters to fill the entire probe!

Performance benefits you can use today:

• Low solvent consumption (mLs per day) for economical operation and minimal waste
• Full solvent gradient capability including step gradients
• Solvent Conditioning (protonated-to-deuterated, on-column solvent exchange)
• High mass sensitivity without compromising chromatographic integrity
• High solvent compatibility due to a totally fused silica capillary design.
• Excellent chromatographic and NMR spectral resolution
• Solvent management (sparge, blanket, degas) available from MRM
• Fully compatible with Varian, Bruker, and JEOL spectrometer systems
• Flow-through probe design virtually eliminates sample carryover

MRM probes are designed with capillary-scale fluidics for flow-injection and LC-NMR analysis. Our limits of detection in a 600 MHz magnet are S/N > 10 (anomeric proton) for 80 scans in 3 minutes using a 3 microliters injection (3 nmol, 1 mg injected) of 1 mM sucrose.  Spectral linewidths are better than 0.8/12/24 Hz (0.11/0.55/50 %), and you’ll find that shimming our probe is relatively simple.  The flowcell volume is approximately 5 microliters, with an active RF coil volume of 1-2 microliters and a total probe volume (including feed lines) of approximately 7 microliters.  This means that the ability to obtain meaningful data in reasonable times from only a few microliters of sample is now a reality.  Other benefits of working at the capillary scale include very low consumption of fully deuterated solvents (dollars per day), and the ability to maintain excellent chromatographic (sample peak) integrity while transporting the sample over distances of 5-10 meters of transfer line and under stopped-flow conditions.  The flow-through probe design eliminates complicated flushing procedures between subsequent sample injections.

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