“Park” for free!
One of the most noteworthy features of capillary-scale fluidics is the ability to transport microliter volume samples over distances of 5-10 meters with virtually no degradation in analyte peak volume. Equally significant, the effects of diffusion and mixing at the capillary scale are very limited so that peaks can literally be parked overnight for resumption of the chromatographic run the following day, with negligible loss of S/N. These two traits, unique to capillary-scale fluidics, are of critical importance to NMR. Safe access to high-field magnets is readily facilitated by remote positioning of the sample management hardware, and the ability to park peaks in the NMR flowcell without degradation to subsequent peaks represents a major benefit, particularly when analyzing low mass samples using multi-dimensional techniques. In this manner, the application is enabled without compromise to sample integrity.

Improve your LC-NMR performance!
The combination of the Waters CapLC and the MRM µFlowProbe allows complex mixtures of small sample mass to be characterized completely, making this technique ideal for applications such as drug discovery, combinatorial chemistry, natural product identification, metabolic studies, and trace contaminant analysis. The use of steep solvent gradients is completely compatible with equilibration times (of both composition and magnetic homogeneity) typically less than 20 minutes. Furthermore, the integrated design of the Waters CapLC allows most separations to be readily downscaled from conventional methods, with minimal adjustments. And since all wetted surfaces in the system are stainless steel or fused silica, all solvents commonly used in chromatography today are compatible - even long term use of DMSO!

MRM’s µFlowProbe will work with your NMR!
MRM probes are compatible with Bruker, Varian and JEOL NMR spectrometers. Currently offered are proton detect/deuterium lock probes designed for 300 MHz – 600 MHz operation. Typical lead time is less than 90 days from the time the order is placed. Installation support is provided at nominal cost, and MRM staff work closely with Waters field engineers for installation of the CapLC-uNMR hypenated system.